Investigation for anti-tumor effects of CIK cells induced by TLR7 agonist instead of IFN-γ / 中国免疫学杂志
Chinese Journal of Immunology
; (12): 1157-1159, 2016.
Article
in Zh
| WPRIM
| ID: wpr-495093
Responsible library:
WPRO
ABSTRACT
Objective:To investigate the immune effects of CIK cells induced by Toll like receptor 7 agonist (Tlr7a) instead of IFN-γon killing lymphoma cells in vitro .Methods: Mononuclear cells were isolated from healthy human peripheral blood .CIK were induced by Tlr7a in vitro instead of IFN-γ.Two groups were divided as follows:CIK group,Tlr7a-CIK group.Then the main investigation on immune effects included immune phenotype was detected respectively , and cytotoxicity of the effectors was analyzed .Results: In Tlr7a-CIK group,the amount of CD56+cells was more than CIK group (P<0.05),and the cytotoxicity was also stronger (P<0.05). Conclusion:Tlr7a instead of IFN-γcould promote the immune effects of CIK cells on killing tumor cells in vitro .
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Immunology
Year:
2016
Type:
Article