Roles of glutamate transporter EAAT2 in occurrence and treatment of depression / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 894-897, 2016.
Article
in Zh
| WPRIM
| ID: wpr-495143
Responsible library:
WPRO
ABSTRACT
The glutamate transporter EAAT 2 ( rodent nomencla-ture GLT-1glutamate transporter 1), which is a predominantly astroglial glutamate transporter in the hippocampus and the pre-frontal cortex , is responsible for the majority of extracellular glu-tamate uptake .The glutamate transporter EAAT 2 can decrease the high levels of glutamate in the synaptic cleft , avoiding gluta-matergic excitotoxicity to damage the glial cells and neurons . Currently, the transporter EAAT2 has become a research hotspot of depression .This article aims to summarize roles of glutamate transporter EAAT2 in the occurrence and treatment of depres-sion.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2016
Type:
Article