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Efficacy and Safety of Calf Spleen Extract Injection Combined with Chemotherapy in the Treatment of Can-cer:A Meta-analysis / 中国药房
China Pharmacy ; (12): 5119-5122, 2015.
Article in Chinese | WPRIM | ID: wpr-501335
ABSTRACT

OBJECTIVE:

To systematically review the efficacy and safety of Calf spleen extract injection combined with chemo-therapy in the treatment of cancer,and provide evidence-based reference for clinical treatment.

METHODS:

Retrieved from Co-chrane Library,PubMed,Medline,EMBase,CJFD,Wanfang and VIP Database,randomized controlled trials(RCT)of the effica-cy and safety about Calf spleen extract injection combined with chemotherapy in the treatment of cancer were collected. Meta-analy-sis was performed by using Rev Man 5.0 software after data extract and quality evaluation by Cochrane 5.0.

RESULTS:

Totally 23 RCT were enrolled,including 1 682 patients. Results of Meta-analysis showed Calf spleen extract injection combined with chemo-therapy in the treatment of cancer can significantly improve the effective rate [OR=2.17,95%CI(1.68,2.81),P<0.001] and im-provement rate of life quality [OR=4.26,95%CI(2.47,7.32),P<0.001] and also reduce the degree rate of WBC and PLT,the inci-dence rate of nausea and emesis,the differences were statistically significant.

CONCLUSIONS:

Calf spleen extraction injection combined with chemotherapy has good efficacy and safety in the treatment of cancer.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Systematic reviews Language: Chinese Journal: China Pharmacy Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Systematic reviews Language: Chinese Journal: China Pharmacy Year: 2015 Type: Article