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Optimization of Extraction Technology for Baiyi Rectal Solution / 中国药房
China Pharmacy ; (12): 3145-3147, 2016.
Article in Chinese | WPRIM | ID: wpr-504869
ABSTRACT

OBJECTIVE:

To optimize the extraction technology of Baiyi rectal solution.

METHODS:

The effects of water amount and extraction time on extraction technology were investigated by central composite design-response surface method using OD value of berberine hydrochloride and ferulic acid and the extract yield as index. Validation test was also conducted.

RESULTS:

The optimal extraction technology was as 11-fold water,decocting 70 min for the first time;5-fold water,decocting 30 min for the second time. In validation test,OD value of first extraction was 0.940 0,and the bias between observed and predicted values was -2.07%;that of second extraction was 0.851 8,and the bias was -2.41%.

CONCLUSIONS:

The extraction technology of Baiyi rectal solution is reasonable,feasible and suitable for industrial production.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2016 Type: Article