Research progress in the Notch pathway in malignant tumors / 实用肿瘤学杂志
Practical Oncology Journal
;
(6): 57-60, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-507138
ABSTRACT
Notch signaling is one of the most important signaling pathways in vertebrates and inverte -brates.It regulates apoptosis,proliferation,differentiation and so on.The up -regulation,down -regulation or structural changes of Notch signal are closely related to the development of various malignant tumors .In the pres-ent study,four Notch phenotypes(Notch1-4)have been identified,which bind to their ligands respectively (Jag-ged1,Jagged2,Delta1,Delta3,Delta4).Notch plays an important role in a variety of malignant tumors .This review focuses on the role of Notch in a variety of solid malignancies ,including its role in the process of tumor develop-ment and treatment .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Practical Oncology Journal
Year:
2017
Type:
Article
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