Effects of propofol on myocardial ? adrenergic receptor in rats / 中华麻醉学杂志
Chinese Journal of Anesthesiology
;
(12)1995.
Article
in Chinese
| WPRIM
| ID: wpr-516802
ABSTRACT
Objective:
To study the effect of the bolus propofol on myocardial ? adrenergic receptor.Method:
Twenty-one,aging 4-6 weeks,male health SD rats,were divided randomly into three groupslow dose group (L)with propofol of 5mg/kg,high dose group(H)with 12mg/kg of propofol and control group(C) with NS alone. The drugs were administered through the rat's tail vein in conscious state. 3 minutes after administration,the raps heart were totally taken out to investigate rat's myocardial ? adrenergic receptors with radioligand binding assay.Result:
Compared with those in control group,in L group there was a decrease in ? adrenergic receptor density(Bmax),but no change in the affinity of ? adrenergic receptor (KD); In H group,Bmax decreased,KD value increased. The Bmax and KD were significantly different between L and H group.Conclusion:
Intravenous bolus doses of propofol may cause down-regulation on myocardial ? adrenergic receptor of rats in dose-related way.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Anesthesiology
Year:
1995
Type:
Article
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