Preparation and Quality Evaluation of Clarithromycin Microcapsules / 中国药房
China Pharmacy
;
(12)2005.
Article
in Chinese
| WPRIM
| ID: wpr-532242
ABSTRACT
OBJECTIVE:
To prepare and evaluate the quality of clarithromycin microcapsules.METHODS:
Clarithromycin microcapsules were prepared by emulsion-solvent volatilixation method using ethylcellulose as capsule wall material.The particle size,entrapment efficiency,the loading amount and the drug release property in vitro were investigated.RESULTS:
The prepared microcapsules were well-distributed in particle size with average particle size at 33.0~38.0 ?m,encapsulation efficiency at above 87%,loading amount above 45%,and accumulative drug release rate of 75% at 6 h.CONCLUSION:
The method is simple and feasible and the quality of prepared microcapsules is up to the standard.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2005
Type:
Article
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