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Preparation and Physicochemical Property of Epirubicin Hydrochloride Solid Lipid Nanoparticles / 中国药房
China Pharmacy ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-532788
ABSTRACT

OBJECTIVE:

To prepare epirubicin hydrochloride solid lipid nanoparticle(EPI-SLN) and investigate its physicochemical property.

METHODS:

EPI-SLN was prepared by ultrasonic dispersion technique with glyceryl behenate as matrix,and the appearance,particle size,? electric potential,and entrapment efficiency of the SLN were evaluated and its stability at 3 month storing at 4 ℃ was investigated.

RESULTS:

EPI-SLN assumed spherical shape with a particle diameter of (212.8?6.2) nm,? electric potential of (-24.7?0.3) mV and entrapment efficiency of 82 %. The EPI-SLN at 4 ℃ was stable after storing for 3 months,showing no marked change in mean diameter,? electric potential or entrapment efficiency.

CONCLUSION:

The prepared EPI-SLN is up to the standard.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article