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Determination of the Content of Vitamin A Palmitate and Its Related Substances by HPLC / 中国药房
China Pharmacy ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-532798
ABSTRACT

OBJECTIVE:

To establishment the method for the determination of content of vitamin A palmitate(VAP) and its related substances by HPLC.

METHODS:

The HPLC conditions were consisted of Phenomenex Luna C18 column with a mobile phase of a mixture of acetonitrile-isopropanol (90∶10) ,the detection wavelength of 328 nm,the column temperature of 30 ℃ and the flow rate of 1.0 mL?min-1.

RESULTS:

VAP was completely separated from impurities,the linearity range was 90~400 mg?L-1(r=0.999 2). The average recovery rate was 99.60% (RSD=1.32%). The average content of the related substances were lower than 2.53% .

CONCLUSION:

This accurate and reliable HPLC method is applicable for the quality control of VAP.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacy Year: 2007 Type: Article