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Determination of Picamilon in Human Plasma by LC-MS / 中国药房
China Pharmacy ; (12)1991.
Article in Zh | WPRIM | ID: wpr-533334
Responsible library: WPRO
ABSTRACT
OBJECTIVE:To establish an LC-MS method for determination of picamilon in human plasma. METHODS:Picamilon and repaglinide(as internal standard)were separated on Agilent C18 column,using methanol-water(85 ∶ 15) as the mobile phase at a flow rate of 0.2 mL?min-1. Column temperature was set at 20 ℃. SIM was used for determination of picamilon in human plasma.Ion mass spectral(m/z) of 207.0→121.1 was selected for picamilon and 451.3→379.2 for repaglinide.RESULTS:The linear range was 50~10 000 ?g?L-1(r=0.999 1); the method recovery was within 99.14%~104.27%. The RSD of inter-day and intra-day validation were 2.12%~5.94% and 7.30%~8.44%,respectively. CONCLUSION:The method is sensitive and accurate for the determination of picamilon in human plasma and its pharmacokinetic study.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: China Pharmacy Year: 1991 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: China Pharmacy Year: 1991 Type: Article