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INFLUENCE OF SB ON PHARMACOKINETICS AND THE ANTI-INFLAMMATORY ACTION OF ASP IN A LARGE DOSE / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences) ; (6)1981.
Article in Chinese | WPRIM | ID: wpr-534938
ABSTRACT
Influence of Sodium Bicarbonate (SB) in several doses on some pharmacokinetic parameters and the anti-inflammatory action of Aspirin (ASP) in a large dose was studied in rats of experimental inflammatory model. It was showed that SB significantly reduced the Tp, T_(1/2), AUC and increased the Ke, Cmax of plasma salicylic acid (SA). The anti-inflammatory effect of ASP was diminished as well. All of the changes, were enhanced as the doses of SB increased. The results in this paper suggested that combining ASP with SB in antirheumatic therapy might be an unreasonable regime.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Xi'an Jiaotong University(Medical Sciences) Year: 1981 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Xi'an Jiaotong University(Medical Sciences) Year: 1981 Type: Article