Inhibitory effect of pioglitazone on TGF-?1 gene expression in renal cortex of diabetic rats / 中华内分泌代谢杂志

ABSTRACT

Diabetic model of SD rats was induced by streptozotocin injected intraperitoneally. Transforming growth factor (TCF)-?1 mRNA level was significantly decreased in renal cortex of diabetic rats by treatment of Pioglitazone. The result suggests that the protection of Pioglitazone against diabetic nephropathy seems to be related to the decrease of TGF-?1 gene expression in renal cortex.