The Role of Lipid Peroxidation in Lung Damage after Smoke Inhalation / 第三军医大学学报

ABSTRACT

The role of lipid peroxidation in the precipitation of umg damage after smoke inhalation was investigated in 16 dogs. Superoxide dismutase(SOD) activity and plasma MDA in arterial blood, and ethane in the exhaled air were determined to demonstrate oxygen free radicals and lipid peroxidation. PaO2 and extravascular lung water (EVLW) were determined to evaluate lung damage.It was found that in the early postinjury period, the experimental animals suffered from pulmonary edema and acute pulmonary dysfunction. MDA in arterial plasma and exhaled ethane markedly increased (P