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The effects of tetrandrine on metabolism of prostaglandin and lipids in patients with essential hypertension / 中国药理学通报
Article in Chinese | WPRIM | ID: wpr-550970
Responsible library: WPRO
ABSTRACT
The effects of tetrandrine on serum TXB2, 6 - Keto - PGF1?, LPO and lipids in patients(n= 40)with essential hypertension has been studied. The results showed that (1) The levels of serum 6 - Keto -PGF1?,apoA1 in EHT were lower and the level of serum TXB2,LPO and apoB100 were higher than those in control. (2)Patients with essential hypertension treated with tetrandrine (0.1 ~ 0. 2g,tid,po)for 3 mon revealed that thelevels of TXB2, LPO and apoB100 were decreased, and the levels of apoA1 and 6 - Keto - PGF1? were increased. In conslusion,tetrandrine stimulated the synthesis of PGI2 and inhibited the release of TXA2 and normalized the metabolism of lipids in patients with essential hypertension.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 1986 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pharmacological Bulletin Year: 1986 Type: Article