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Humoral immune response to gene vaccine against adr hepatitis B virus / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-552227
ABSTRACT

Objective:

To construct HBV adr gene vaccine pCMVS 2-S and to observe the specific humoral immune responses in C57BL/6 mice after gene immunization.

Methods:

The HBV gene vaccine was injected into tibialis anterior muscles of C57BL/6 mice. ELISA was used to detected the anti-HBs antibody in mice sera at various time points after gene transfer.

Results:

Anti-HBs in sera of mice was tested positive 1 week after plasmid injected, the level of antibody peaked 4 weeks later, and kept high titer for at least 2 months.

Conclusion:

The good response of humoral immunity can be induced by injection of pCMVS 2-S in C57BL/6 mice.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article