Silent Colonic Malakoplakia in a Living-Donor Kidney Transplant Recipient Diagnosed during Annual Medical Examination
Korean Journal of Pathology
; : 163-166, 2013.
Article
in En
| WPRIM
| ID: wpr-56546
Responsible library:
WPRO
ABSTRACT
Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies one or several round basophilic structures of approximately 1 to 10 microm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma Cells
/
Polyps
/
Basophils
/
Biopsy
/
Lymphocytes
/
Colonoscopy
/
Kidney Transplantation
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Immunocompromised Host
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Colon
/
Transplants
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Korean Journal of Pathology
Year:
2013
Type:
Article