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Relative bioavailability of Ophiopogon japonicus saponin enteric microsphere in rats / 中草药
Zhongcaoyao ; Zhongcaoyao;(24)1994.
Article in Zh | WPRIM | ID: wpr-573587
Responsible library: WPRO
ABSTRACT
Objective To study the relative bioavailability after ig rats with Ophiopogon japonicus saponin enteric microsphere in single-dose so as to give directly preparation quality evaluation. Methods(Establishing the) analysis method of HPLC-MS and dealing with the blood sample by solid phase extraction. Determining the diosgenin concentration in plasma after ig Ophiopogon japonicas saponin enteric microsphere and the suspension as comparison in single-dose, and calculating pharmacokinetic parameters and relative bioavailability. Results C_(max), t_(max), and AUC_(0-72) were (637.81?17.23) ng/mL, (4.0?0.0) h, and 7 840.01?412.03, respectively. Conclusion The characteristics of absorption, distribution, and elimination are resembled in rats between two preparations by ig in single-dose. The pharmacokinetic parameters are also identical. The relative bioavailability is (91.10?3.44)%.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Zhongcaoyao Year: 1994 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Zhongcaoyao Year: 1994 Type: Article