Effects of anti-CXCR4 monoclonal antibody 12G5 on adhesion and invasion of gastric cancer cells / 重庆医科大学学报

ABSTRACT

Objective:To investigate the effects of anti-CXCR4 monoclonal antibody 12G5 on adhesion and invasion of SGC7901 cells.Methods:The effects of 12G5(5?g/ml,10?g/ml and 20?g/ml, respectively)on the adhesive、invasive and migrative abilities of SGC7901 cells were explored by MTT and Transwell chamber. Results:(1)12G5 showed a time/dose-dependent inhibition effect on SGC7901 cells adhering Matrigel,and the adhesion of gastric cancer cells was inhibited on the concentration of 10?g/ml of 12G5, and compared with untreated group,adhesion of SGC7901 cells was signficantly lower(P