Analysis of Neurotoxicity Caused by Cefepime / 药物流行病学杂志

ABSTRACT

Objective:To analyze domestic and foreign literatures which carried the reports of neurotoxicity induced by cefepime in order to warn the clinic to pay attention to its possible neurotoxicity and to avoid the occurrence of its serious adverse drug effects.Method:The literatures were searched for on www.cnki.net and PUBMED which reported the neurotoxicity induced by cefepime from 1999 to 2009 and the rules and characteristics of neurotoxicity induced by cefepime were analyzed.Result:71 articles including 53 Chinese articles and 18 English articles about neurotoxicity due to cefepime were collected.There were 36 case reports in these articles.The median age was 64.5 years and there was one death case, the mortality being 2.8%.Conclusion:The neurotoxicity induced by cefepime is closely related to patients' ages and kidney functions,but has little relationship to patients' genders and drug dosages.