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Optimization of total epimediumon flavone microporosity osmotic pump tablet formulation by box-behnken design and response surface methodology / 中成药
Article in Chinese | WPRIM | ID: wpr-581162
Responsible library: WPRO
ABSTRACT

AIM:

To optimize total flavone of herba epimediumon microporosity osmotic pump tablets by boxbehnken design-response surface methodology.

METHODS:

Osmotic agent (lactose),dosage of plastificator (dibutyl phthalate),and coating weight gain were selected as key factors of influencing total flavone delivery. Total flavones cumulatiive yield in 12 h and fitting approximation was regarded as the response. Design Expert method useful for the modeling and analysis was to optimize the response.

RESULTS:

Response surface surface obtained repre-sented maximum one which conformed to the zero-order delivery rate equation.

CONCLUSION:

Optimal excipient formulation of total epimedium flavone microporosity osmotic pump tablet consists of 0. 18 g of lactose,0. 26 ratio of dibutyl phthalate to acetyl celulose and 7. 7% of coating weight gain.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 1992 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Traditional Patent Medicine Year: 1992 Type: Article