Neurodevelopmental Changes in Social Reinforcement Processing: A Functional Magnetic Resonance Imaging Study
Clinical Psychopharmacology and Neuroscience
; : 369-381, 2017.
Article
in En
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| ID: wpr-58957
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ABSTRACT
OBJECTIVE: In the current study we investigated neurodevelopmental changes in response to social and non-social reinforcement. METHODS: Fifty-three healthy participants including 16 early adolescents (age, 10–15 years), 16 late adolescents (age, 15–18 years), and 21 young adults (age, 21–25 years) completed a social/non-social reward learning task while undergoing functional magnetic resonance imaging. Participants responded to fractal image stimuli and received social or non-social reward/non-rewards according to their accuracy. ANOVAs were conducted on both the blood oxygen level dependent response data and the product of a context-dependent psychophysiological interaction (gPPI) analysis involving ventromedial prefrontal cortex (vmPFC) and bilateral insula cortices as seed regions. RESULTS: Early adolescents showed significantly increased activation in the amygdala and anterior insula cortex in response to non-social monetary rewards relative to both social reward/non-reward and monetary non-rewards compared to late adolescents and young adults. In addition, early adolescents showed significantly more positive connectivity between the vmPFC/bilateral insula cortices seeds and other regions implicated in reinforcement processing (the amygdala, posterior cingulate cortex, insula cortex, and lentiform nucleus) in response to non-reward and especially social non-reward, compared to late adolescents and young adults. CONCLUSION: It appears that early adolescence may be marked by: (i) a selective increase in responsiveness to non-social, relative to social, rewards; and (ii) enhanced, integrated functioning of reinforcement circuitry for non-reward, and in particular, with respect to posterior cingulate and insula cortices, for social non-reward.
Key words
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Index:
WPRIM
Main subject:
Oxygen
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Reinforcement, Social
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Reward
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Magnetic Resonance Imaging
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Prefrontal Cortex
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Fractals
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Healthy Volunteers
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Gyrus Cinguli
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Amygdala
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Learning
Limits:
Adolescent
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Humans
Language:
En
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2017
Type:
Article