Spatial Allocation and Specification of Cardiomyocytes during Zebrafish Embryogenesis
Korean Circulation Journal
;
: 160-167, 2017.
Article
in English
| WPRIM
| ID: wpr-59352
ABSTRACT
Incomplete development and severe malformation of the heart result in miscarriage of embryos because of its malfunction as a pump for circulation. During cardiogenesis, development of the heart is precisely coordinated by the genetically-primed program that is revealed by the sequential expression of transcription factors. It is important to investigate how spatial allocation of the heart containing cardiomyocytes and other mesoderm-derived cells is determined. In addition, the molecular mechanism underlying cardiomyocyte differentiation still remains elusive. The location of ectoderm-, mesoderm-, and endoderm-derived organs is determined by their initial allocation and subsequent mutual cell-cell interactions or paracrine-based regulation. In the present work, we provide an overview of cardiac development controlled by the germ layers and discuss the points that should be uncovered in future for understanding cardiogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Zebrafish
/
Abortion, Spontaneous
/
Cilia
/
Myocytes, Cardiac
/
Embryonic Development
/
Embryonic Structures
/
Germ Layers
/
Heart
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Korean Circulation Journal
Year:
2017
Type:
Article
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