Effect of sibutramine on intraocular pressure
Philippine Journal of Ophthalmology
; : 35-37, 2006.
Article
in En
| WPRIM
| ID: wpr-632252
Responsible library:
WPRO
ABSTRACT
OBJECTIVE: This study evaluated the effects of sibutramine on intraocular pressure (IOP) and body-mass index (BMI). METHODS: Thirty obese females (body-mass index>30 kg/m2) treated with sibustramine (10 mg/day) plus plus diet restriction for 3 months were included in the study. IOP, BMI, and blood biochemical parameters were measured at the beginning and end of the treatment. Results were evaluated statistically by paired t-test, analysis of variance, and least-significant difference test. RESULTS: A statistically significant decrease was observed in the mean body-mas index (p<0.001) ans serum triglyceride (p<0.001), while a statistically significant increase was observed in IOP (p=0.54). CONCLUSION: While sibustramine provided an effective means for weight loss, it caused a slight increase in IOP, although this was not statistically significant. Nevertheless, it is prudent to monitor IOP in selected obese patients treated with sibustramine.
Full text:
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Index:
WPRIM
Main subject:
Intraocular Pressure
/
Obesity
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Philippine Journal of Ophthalmology
Year:
2006
Type:
Article