Analysis on bone refracture in patients with hormone induced osteoporotic thoracolumbar vertebral fractures treated with PVP / 重庆医学

ABSTRACT

Objective To investigate the refracture and risk factors after percutaneous vertebroplasty (PVP) in the patients with hormone induced osteoporotic thoracolumbar vertebral fracture.Methods A total of 646 patients with osteoporotic thoracolumbar vertebral fractures in 425 Central Hospital of PLA from April 2010 to July 2015 were selected and divided into the primary osteoporotic thoracolumbar vertebral fractures(n=542) and hormone-induced osteoporotic thoracolumbar vertebral fractures(n=104) according to the fracture types.The incidence rate of refracture was compared between the two types of patients.The patients with hormone induced osteoporotic thoracolumbar fractures were divided into the fracture group and non-fracture group according to the refracture occurrence situation.The clinical data of the two groups were performed the univariate and multivariate Logistic regression analysis.Results There were 542 cases of primary osteoporosis,102 cases had refracture with the incidence rate of 18.82％,104 cases had hormone induced osteoporosis and 53 cases had refracture with the incidence rate of 50.96％.BMI,bone mineral density,bone cement leakage,preoperative vertebral fissure change and proportion of unreceiving anti-osteoporosis treatment had statistical difference between the fracture group and non-fracture group (P＜0.05).Bone mineral density,bone cement leakage,preoperative vertebral fissure change and no anti-osteoporosis treatment were the independent risk factors for refracture after PVP operation in the patients with steroid-induced thoracolumbar vertebral fracture (P＜0.05).Conclusion The patients with hormone induced osteoporotic thoracolumbar vertebral fracture have higher risk of refracture.Bone mineral density,bone cement leakage,preoperative vertebral fissure change,whether accepting anti-osteoporosis treatment are the major risk factors of refracture.