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Clinical characteristics and prognosis of patients with malignant tumor of digestive system combined with venous thromboembolism / 中华老年医学杂志
Chinese Journal of Geriatrics ; (12): 1075-1079, 2017.
Article in Chinese | WPRIM | ID: wpr-660631
ABSTRACT
Objective To explore the clinical characteristics and prognosis of patients with malignant tumor of digestive system combined with venous thromboembolism(VTE).Methods The clinical data of 77 patients admitted in Beijing Hospital from January 2003 to April 2013 with digestive system malignant tumor complicated with VTE were retrospectively analyzed.The incidence,clinical features and prognosis of the patients with digestive system cancer were analyzed.Results Among 77 patients,57 cases of male and 20 cases of female were involved,with an average age of(68.7 ± 12.4)years,including 60 cases(77.9 %)of adenocarcinoma.The pathological results showed that differentiated tumors accounted for 61.0% (47/77).Among the 77 patients,pulmonary thromboembolism (PTE) accounted for 33.8 % (26 cases) and deep vein thrombosis(DVT)in the low extremities accounted for 66.2 % (51 cases).Among all the patients,the most common symptoms were dyspnea and swelling or pain in the extremities.The incidence of VTE was 24.7% (19/77),13.0%(10/77),19.5%(15/77),5.2%(4/77),5.2% (4/77),32.5% (25/77) at 1,3,6,9,12,> 12 months after diagnosis of digestive system malignancies,respectively.By April 2013,the 54.5 % (42/77) patients died,among which 73.8 % (31/42) died of digestive system malignancies,11.9 % (5/42) died of PTE,14.3 % (6/42) died of other causes.The mortality rates at 1,3,6,9,12,> 12 months after the diagnosis of VTE were 20.8% (16/77),6.5 % (5/77),13.0 % (10/77),5.2 % (4/77),2.6 % (2/77),6.5 % (5/77),respectively.The difference in VTE incidence between the group aged ≥65 years and group aged <65 years at 1,3,6,9 and 12 months after the diagnosis of tumors was not statistically significant(P =0.309).The differences in mortality(P =0.357) and in the median survival time(x2 =0.290,P =0.591) between the two groups were not statistically significant at 1,3,6,9 and 12 months after the diagnosis of VTE.Conclusions The risks for VTE are high in patients with digestive tract malignant tumor,advanced malignant tumor,poor histologic grade(poorly or moderately differentiation),and chemotherapy or surgery,which mostly occurs within 3-6 months after diagnosis.Most deaths occur within the 1st year after the diagnosis of VTE.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Geriatrics Year: 2017 Type: Article