The role of plasma exchange in treatment of postpartum HELLP syndrome / 重庆医学

ABSTRACT

Objective To explore the clinical effect of plasma exchange on postpartum HELLP syndrome.Methods From January 2014 to December 2015,44 patients with postpartum HELLP syndrome were chosen as the treatment group which received conventional treatment combined with plasma exchange.And we selected 47 patients with postpartum HELLP syndrome as the control group from January 2012 to December 2013.Serum hemoglobin(Hb),platelet(PLT),prothrombin time(PT),serum aspartate aminotransferase (AST),alanine aminotransferase (ALT),serum total bilirubin (TBIL),conjugated bilirubin(DBIL) and serum lactic dehydrogenase(LDH),blood urea nitrogen(BUN) and creatinine(Cr) level in patients with postpartum HELLP syndrome were detected before and after the treatment.The ICU stay,recovery time of PLT,ALT,AST,and LDH were compared between two group.Results After treatment,the levels of PLT,AST,ALT and LDH in the treatment group were significantly higher than those in the control group (P＜0.05).The ICU stays and the recovery time of PLU,ALT,AST and LDH in the treatment group were significantly lower than the control group (P＜0.05).Conclusion Plasma replacement can significantly improve the clinical symptoms of postpartum HELLP syndrome patients,improve the cure rate.