Value of parotid gland carcinoma tissue PAX2 and PAX8 expression for jointly predicting recurrence and metastasis after radical surgery / 重庆医学

ABSTRACT

Objective To investigate the value of parotid gland carcinoma tissue PAX2 and PAX8 expression for combined prediction of recurrence and metastasis after radical surgery.Methods Forty-six patients with parotid gland carcinoma treated by parotid gland joint neck radical operation served as the research subjects.The immunohistochemical method was applied to detect the PAX2 and PAX8 protein expression level in surgical removal parotid gland carcinoma tissues and tissues adjacent to carcinoma.Results The PAX2 and PAX8 protein positive expression rates of parotid gland carcinoma tissue were 76.09％ and 69.57％ respectively,which were higher than 26.09 ％ and 28.26 ％ in the tissue adjacent to carcinoma (P＜0.05).The local recurrence rate in the patients with parotid gland carcinoma radical operation and 3-year follow-up was 41.30％,and lymph node metastasis rate was 34.78％.Moreover the metastasis and recurrence rate in the patients with PAX2 protein positive expressing were higher than those in the patients with PAX2 negative expression,and the metastasis and recurrence rate in the patients with PAX8 protein positive expressionwere higher than those in the patients with PAX8 negative expression (P＜0.(05).The Logistic regression analysis results showed that parotid gland carcinoma tissue PAX2 and PAX8 expression levels had close correlation with the recurrence and metastasis after radical surgery were closely correlated (P＜0.05).Parotid gland carcinoma tissue PAX2 and PAX8 expression levels for predicting the post-operative recurrence and metastasis had good value,in which the value of PAX2 positive and PAX8 positive expression for predicting the recurrence and metastasis was optimal.Conclusion Parotid gland carcinoma tissue PAX2 and PAX8 expression levels are closely correlated with the prognosis situation such as recurrence and metastasis after radical surgery,moreover their combined detection has better value for predicting the prognosis,which can serve as the reference indicator for the prognosisassessment after radical operation of parotid gland carcinoma.