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Diagnostic value of procalcitonin for articular infection in adults: a meta-analysis / 中国组织工程研究
Chinese Journal of Tissue Engineering Research ; (53): 5078-5084, 2017.
Article in Chinese | WPRIM | ID: wpr-667989
ABSTRACT

BACKGROUND:

Due to special physiological characteristics, articular infection is difficult to be cured successfully. Early diagnosis is critical for the treatment of articular infection, thereafter, searching for a biomarker with high sensitivity and specificity is necessary.

OBJECTIVE:

To systematically evaluate the value of procalcitonin for diagnosing joint infection in adult.

METHODS:

A computer-based online research was performed for the literature in PubMed, EMbase, the Cochrane Library and CNKI databases from 1990 to June 2017. Literature screening and data extraction were conducted by two reviewers independently according to the inclusion and exclusion criteria. The risk of bias of included studies was assessed by using the Quality Assessment of Diagnostic Accuracy Studies-2. Meta-analysis was then performed using Stata 14.0 software. The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio were calculated; the summary receiver operating characteristic curve was drawn and the area under the curve was calculated.RESULTS AND

CONCLUSION:

(1) A total of 10 studies were included, involving 893 patients. (2) The pooled weighted sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of procalcitonin diagnosing joint infection were 0.82 (95%CI=0.72-0.89), 0.89 (95%CI=0.82-0.93), 7.20 (95%CI=4.6-11.3), 0.20 (95%CI=0.13-0.32), 35 (95%CI=18-71) and 0.92 (95%CI=0.90-0.94), respectively. (3) To conclude, procalcitonin exhibits more diagnostic efficiency for assessing articular infection in adults.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Screening study / Systematic reviews Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Diagnostic study / Prognostic study / Screening study / Systematic reviews Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2017 Type: Article