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Determination of Gabapentin and Related Substances in Gabapentin Capsules by HPLC / 中国药师
China Pharmacist ; (12): 520-522, 2015.
Article in Chinese | WPRIM | ID: wpr-669664
ABSTRACT

Objective:

To establish an HPLC method for the determination of gabapentin and the related substances in gabapentin capsules.

Methods:

A Kromasil C8 column (250 mm × 4. 6 mm,5μm)was used. The mobile phase was methanol-0. 01 mol·L-1 po-tassium dihydrogen phosphate solution (adjusting pH to 6. 9 with 2 mol·L-1 potassium hydroxide) (40∶60). The detection wave-length was 210 nm. The column temperature was 40℃ and the injection volume was 20μl. The main component and the known impuri-ty were determined by an external standard method. The unknown impurities were determined by a self-control method.

Results:

The calibration curve of gabapentin was linear within the range of 2.5-20.0 mg·ml-1(r=0.999 9). The average sample recovery was 100. 74% with RSD of 0. 24%(n=5).

Conclusion:

The method is simple, accurate,specific and applicable in the determination of gabapentin and the related substances in gabapentin capsules.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: China Pharmacist Year: 2015 Type: Article