Effect of Hydroxypropyl Starch Vacant Capsules on the Content of Spironolactone / 中国药师
China Pharmacist
;
(12): 1052-1054, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-669850
ABSTRACT
Objective:
To investigate the effect of vacant capsules made from hydroxypropyl starch on the content of spironolac-tone.Methods:
The spironolactone capsules were placed under the conditions with (4 000 ± 500) lx, 40℃ and RH (75 ± 5) % for 5 days and 10 days, respectively. An HPLC method was used to analyze the content of spironolactone, and the changes in appearance, color and the other traits were also observed.Results:
The content of spironolactone was within the range of 93. 45%-100. 37% after the above tests, which was conformed to the standard(93. 0%-107. 0%).Conclusion:
The vacant capsules made from hydroxypropyl starch rival have good compatibility with spironolactone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2015
Type:
Article
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