Study of a Bio-oss and rhBMP-2 composite repairing the alveolar bone defects around heterogenous implanted teeth / 实用口腔医学杂志

ABSTRACT

Objective: To evaluate the reliability and effects of a compound bone substitute materials Bio-oss artificial bone grafts with recombinant human bone morphogenic protein-2(rhBMP-2) filling the alveolar bone defects around heterogenous replanted teeth. Methods:3 dogs′ bilateral mandible 3rd premolars(6 sites) were extracted. The defect sites without buccal and lingual alveolar bone were prepared for the heterogenous implanted teeth and the compound of Bio-oss and rhBMP-2 filled the alveolar bone defects around. The bone regeneration was observed by naked eye, radiograph, histology and histomorphometric analysis after 2, 3 months. Results:The new alveolar bone showed osteogenesis and calcification after 2 months, and intergrated with implanted teeth root under the light microscope and X ray. The new bone trabecular thickness(Tb.Th) augmented continuously. Differences of the bone area(B.Ar) and bone perimeter(B.Pm) were statistically significant after 2nd and 3rd month(P