Preliminary Studies on Anti-Inflammatory and Analgesic Activities of Optimized Liushen Wan(CNZ) / 中药新药与临床药理
Article
in Zh
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| ID: wpr-683578
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WPRO
ABSTRACT
Objective To observe the anti-inflammatory and analgesic effects of CNZ,an optimized prescrition of Liushen Wan based on our previous studies,so as to provide some pharmacological evidence for its further clinical use. Methods Both acetic-acid-induced increased mouse vascular permeability and carrageenan-induced mouse footpad edema were used to study the anti-inflammatory activity of CNZ.Meanwhile,its analgesic activity was evaluated in mice model of pain induced by thermal stimulus and acetic acid.The above activities were compared with those of Liushen Wan.Results CNZ significantly reduced acetic-acid-induced dye leakage at the doses of 16,32 and 64mg/kg after single oral administration.Meanwhile,CNZ at the two higher doses also markedly inhibited carrageenan-induced foot- pad edema,which exerted the strongest effect at 3 hours after carrageenan injection,and lasted over 5 hours.On the other hand,CNZ remarkably suppressed acetic-acid-induced writhing response at low,moderate-and high-doses, and significantly prolonged pain threshold in hot plate assay at moderate-and high-doses 0.5 hour after oral adminis- tration,lasting over 3 hours.Overall,its potency was similar to that of Liushen Wan.Conclusion CNZ has significant anti-inflammatory and analgesic activities.
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WPRIM
Language:
Zh
Journal:
Traditional Chinese Drug Research & Clinical Pharmacology
Year:
1993
Type:
Article