OPTIMIZATION OF THE MEDIUM AND PROCESS PARAMETERS IN BATCH AMINOGLYCOSIDE ANTIBIOTIC JI-20A FERMENTATION / 微生物学通报

ABSTRACT

The medium and process parameters were optimized in batchaminoglycoside antibiotic JI-20A fennentation. The optimal medium consists mainly of comstarch 60g/L, peanut meal 30g/L, com slurry 8g/L, maltose 10g/L, inorganic compound and amylase moderate , methionin 1g/L and cobalt chloride 6?g/mL. It was significant to adjust medium pH after autoclaving and oxygenate the fennentation medium for the cell growth and JI-20A product.