Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 303-307, 2018.
Article
in Zh
| WPRIM
| ID: wpr-689636
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the predictive value of cord blood 25(OH)D [25(OH)D] for infantile atopic dermatitis (AD), and to provide a reference for primary prevention of early infantile AD.</p><p><b>METHODS</b>The neonates born from July to September, 2015 were enrolled. The cord blood samples were collected at birth to measure the level of 25(OH)D. Outpatient follow-up was conducted for all the infants at 6 weeks, 3 months, and 6 months after birth. A survey was performed to investigate the incidence of AD.</p><p><b>RESULTS</b>A total of 67 neonates completed a 6-month follow-up. The incidence of AD was 34% (23/67), and 91% (21/23) of these cases occurred in the first month after birth. The 23 AD children had a significantly lower cord 25(OH)D level than those without AD (P<0.05). The children with a cord 25(OH)D level <30 nmol/L showed a significantly higher incidence of AD than those with a cord 25(OH)D level ≥30 nmol/L (P<0.05). The receiver operating characteristic (ROC) analysis showed that the area under the ROC curve of cord 25(OH)D in predicting AD was 0.648 (standard error 0.075; 95%CI 0.502-0.795). Its sensitivity, specificity, positive predictive value, and negative predictive value were 52.2%, 79.5%, 57.1%, and 76.1%, respectively. Logistic regression analysis showed that low cord 25(OH)D level, preference for seafood during pregnancy, atopic family history, and mixed feeding were risk factors for infantile AD (P<0.05).</p><p><b>CONCLUSIONS</b>Cord 25(OH)D level is inversely associated with the risk of infantile AD, but it has a low diagnostic value for this disease.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
/
Calcifediol
/
Logistic Models
/
Chemistry
/
Epidemiology
/
Predictive Value of Tests
/
Risk Factors
/
ROC Curve
/
Dermatitis, Atopic
/
Fetal Blood
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2018
Type:
Article