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Comparison of urinary proteomes among rats, guinea pigs and golden hamsters / 生物工程学报
Chinese Journal of Biotechnology ; (12): 578-585, 2018.
Article in Chinese | WPRIM | ID: wpr-690146
Responsible library: WPRO
ABSTRACT
Biomarkers are the detectable changes associated with physiological or pathological changes. Urine as excreta of the body, without the mechanisms to maintain a homeostatic internal environment, can reflect a variety of changes in the body. Using animal models can simulate human disease processes, monitor disease changes, and provide clues to early diagnosis. Rats as commonly used model animals are not the dominant models for all disease, thus comparing the urinary proteins of rats with other animals to provide clues to the selection of other animal dominant models. In this study, urinary proteins were digested and profiled by liquid chromatography and tandem mass spectrometry (LC-MS/MS). The urinary proteins of rats, guinea pigs and golden hamsters were compared. The results showed that the number of urine proteins in the three different animals was different, and also different in every system of the body. This provides a basis for selecting the best animal models for different diseases.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Screening study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Screening study Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2018 Type: Article