Correlation analysis between fentanyl-induced cough and postoperative nausea and vomiting in children / 临床麻醉学杂志

ABSTRACT

Objective To investigate the correlation analysis between fentanyl-induced cough (FIC) and postoperative nausea and vomiting (PONV) in children.Methods A total of 159 childrenwho underwent orthopedic surgery,98 males and 61 females,aged 3-12 years,ASA physical status Ⅰ,were enrolled in this study.Before being taken to the operating room,venous access was established,a fentanyl bolus (3 μg/kg) was injected in 5 s.According to whether or not coughs occurrence up to 1 min after the bolus were divided into cough group (group FIC) and not cough group (group NFIC).The presence of FIC or non-FIC during induction and the occurrence of PONV were respectively recorded.In addition,the incidence and severity of PONV 24 h after surgery were assessed.FIC and other perioperative variables were subjected to multivariate analysis to determine the association between FIC and PONV.Results The incidence of PONV in group FIC was higher than that in group NFIC [33 (54.1 ％) cases vs 36 (36.7％) cases,P ＜ 0.05].There was no significant difference in the severity of nausea and vomiting between the two groups.Multivariate logistic regression analysis found FIC to be a predictive risk factor for the development of PONV (OR =1.508,95％ CI 1.263-1.981).Condusion Children undergoing orthopedic surgery who develop FIC during induction of anaesthesia have a higher incidence of PONV,but the severity of nausea and vomiting has no significant difference.