The value of 3D-ASL parameters for predicting glioma grade before operation and the relationship between the expression of Ki-67 and MVD / 实用放射学杂志
Journal of Practical Radiology
; (12): 654-657,665, 2018.
Article
in Zh
| WPRIM
| ID: wpr-696877
Responsible library:
WPRO
ABSTRACT
Objective To explore the value of 3D-ASL parameters for predicting glioma grade before operation and the relationship between the expression of Ki-67 and microvessel density(MVD).Methods 3DASL images of 50 patients with pathologically proven gliomas (high graden=20,1ow graden 30) were analyzed retrospectively.The mean maximum relative cerebral blood flow was obtained by the hot spot method.The Ki-67 labeling index and MVD of surgical specimen were measured.The results were analyzed statistically.Results The mean rCBF,Ki-67 and MVD of low grade gliomas (n=30) were 1.69±1.27,3.73%±3.01%,25.43±13.03,while the high grade gliomas (n=20) were 3.18± 1.46,49.25% ±20.15%,58.69±20.39 respectively.The difference between the two groups was statistically significant (P<0.01),which was positively correlated with the grade(r=0.620,0.871,0.698,P<0.01).rCBF was positively correlated with Ki-67 and MVD (r =0.535,0.723,P <0.01).Ki 67 labeling index was positively correlated with MVD (r=0.629,P<0.01).Conclusion The rCBF value is useful for predicting glioma grade before operation and related to tumor MVD and cell proliferation.The biologic behavior of glioma can be predicted to a certain extent.
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Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Journal of Practical Radiology
Year:
2018
Type:
Article