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Correlation among plasma levels of hsCRP, Hcy and blood pressure variability in patients with essential hypertension / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 5-9, 2018.
Article in Chinese | WPRIM | ID: wpr-699330
ABSTRACT

Objective:

To explore correlation among plasma levels of high sensitive C reactive protein (hsCRP), homocysteine (Hcy) and blood pressure variability (BPV) in patients with essential hypertension (EH).

Methods:

According to plasma Hcy level, a total of 150 EH patients were divided into low Hcy group (n=58, Hcy<10μmol/L), medium Hcy group (n=69, Hcy 10~20μmol/L) and high Hcy group (n=53, Hcy>20μmol/L); according to plasma hsCRP level, they were divided into low hsCRP group (n=55, hsCRP<5mg/L), medium hsCRP group (n=64, hsCRP 5~10mg/L) and high hsCRP group (n=61, hsCRP>10mg/L). Blood lipids, blood glucose, renal function indexes and BPV were measured and compared among all groups, and the correlation among plasma Hcy, hsCRP levels and BPV were analyzed.

Results:

Compared with low Hcy group, there were significant rise in 24h SBP standard deviation [24hSSD, (13. 26±3. 09) mmHg vs. (15. 68±3. 71) mmHg vs. (18. 39±4. 06) mmHg], daytime SSD [dSSD, (13. 12±3. 20) mmHg vs. (15. 09±3. 73) mmHg vs. (17. 82±3. 83) mmHg]and nighttime SSD [nSSD, (11. 29±2. 60) mmHg vs. (13. 63±2. 74) mmHg vs. (16. 09±2. 80) mmHg]in medium Hcy group and high Hcy group, and those of high Hcy group were significantly higher than those of medium Hcy group, P<0. 01 all. Compared with low hsCRP group, there were significant rise in 24SSD [(13. 35±3. 12) mmHg vs. (16. 04±3. 69) mmHg vs. (18. 55±4. 17) mmHg], dSSD [(12. 96±3. 14) mmHg vs. (15. 18±3. 81) mmHg vs. (18. 05±3. 90) mmHg]and nSSD [(11. 08±2. 53) mmHg vs. (13. 76±2. 85) mmHg vs. (16. 18±3. 05) mmHg]in medium hsCRP group and high hsCRP group, and those of high hsCRP group were significantly higher than those of medium hsCRP group, P=0. 001 all. Pearson correlation analysis indicated that plasma Hcy and hsCRP levels were significant positively correlated with 24hSSD, dSSD and nSSD in EH patients (r=0. 294~0. 419, P<0. 05 all).

Conclusion:

Plasma Hcy and hsCRP levels are significant positively correlated with SBP variability in EH patients. Their monitoring contributes to evaluating their blood pressure variability.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article