Diagnostic value of hsCRP,cTnI and BNP detecting for acute cardiovascular diseases / 心血管康复医学杂志

ABSTRACT

Objective:To explore diagnostic value of high sensitive C reactive protein(hsCRP),cardiac troponin I(cTnI) and brain natriuretic peptide(BNP)detecting for acute cardiovascular diseases(ACVD).Methods:A total of 216 ACVD patients treated in our hospital were selected as ACVD group,another 216 healthy subjects undergoing physical examination during the same period were selected as healthy control group.According to presence of major adverse cardiovascular events (MACE)after treatment,ACVD group was further divided into MACE group(n=52)and no MACE group(n=164). Levels of hsCRP,cTnI and BNP were measured and compared among all groups.Specificity,sensitivity,positive and nega-tive predictive value of single and combined detections of hsCRP,cTnI and BNP for diagnostic ACVD were calculated and compared.Results:Compared with healthy control group,there were significant rise in levels of hsCRP,cTnI and BNP in ACVD group,P=0.001 all.Compared with before treatment,there were significant reductions in levels of hsCRP,cTnI and BNP in ACVD group after treatment,P=0.001 all;in ACVD group,compared with no MACE group after treat-ment,there were significant rise in levels of hsCRP,cTnI and BNP in MACE group,P=0.001 all.With imaging exami-nation as diagnosing gold standard for ACVD,compared with single detection of hsCRP and cTnI,there were significant rise in sensitivity(57.85%,72.32% vs.99.02%),positive predictive value(60.87%,74.31% vs.99.02%)and nega-tive predictive value(49.50%,71.03% vs.81.81%)in combined detection of hsCRP,cTnI and BNP,and specificity of combined detection was significantly higher than those of single hsCRP and BNP detection(81.81% vs.52.63%, 66.67%),P<0.05 or <0.01. Conclusion:Combined detection of hsCRP,cTnI and BNP can accurately diagnose acute cardiovascular diseases,evaluate their prognosis and is worth extending.