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Therapeutic effect of subhypothermia treatment combined cisternal nimodipine perfusion on cerebral vasospasm after subarachnoid hemorrhage / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 289-293, 2018.
Article in Chinese | WPRIM | ID: wpr-699406
ABSTRACT

Objective:

To explore therapeutic effect of subhypothermia combined cisternal nimodipine perfusion (CNP) on cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH).

Methods:

A total of 92 patients with CVS after SAH treated in our hospital from Feb 2014 to May 2016 were selected .The patients were randomly and e-qually divided into subhypothermia group (received subhypothermia treatment ) and combined treatment group (re-ceived subhypothermia treatment combined CNP) ,both groups were treated for 3 d .Therapeutic effect ,Glasgow coma scale (GCS) score ,middle cerebral artery (MCA) mean blood flow velocity ,serum levels of tumor necrosis factor (TNF)-α ,high sensitive C reactive protein (hsCRP) and interleukin (IL)-6 before and after treatment , and incidence rate of adverse events were compared between two groups .

Results:

Compared with before treat-ment ,after treatment ,there was significant rise in GCS score ,and significant reductions in MCA mean blood flow velocity ,serum levels of TNF-α ,hsCRP and IL-6 in two groups , P= 0.001 all ;compared with subhypothermia group after treatment ,there was significant rise in GCS score [ (10.26 ± 2.14) scores vs .(12.35 ± 2.56) scores] , and significant reductions in MCA mean blood flow velocity [(97.48 ± 18.20) cm/s vs.(89.74 ± 18.40) cm/s] ,se-rum levels of TNF-α [(0.56 ± 0.17) ng/ml vs.(0.34 ± 0.11) ng/ml] ,hsCRP [(186.75 ± 15.19) ng/L vs.(173.24 ± 15.23) ng/L] and IL-6 [ (10.41 ± 2.06) ng/L vs .(8.51 ± 2.13) ng/L] in combined treatment group ,P<0.05 or <0. 01. Total effective rate of combined treatment group was significantly higher than that of subhypothermia group (91.30% vs.71.74%) , P=0.016 ;and incidence rate of adverse events was significantly lower than that of subhypothermia group (6.52% vs.21.74%) ,P=0.032 .

Conclusion:

Subhypothermia treatment combined cisternal nimodipine perfusion can effectively reduce MCA blood flow velocity ,relieve inflammation and improve therapeutic effect with less adverse events ,which is worth extending .

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2018 Type: Article