Clinical Characteristics of 65 Male Patients with Sj(o)gren's Syndrome / 医学研究杂志

ABSTRACT

Objective To analyze the different clinical features and system lesions of female and male primary Sj(o)gren's syndrome (pSS) patients and to attract more attention to male pSS patients' pathogenic features.Methods Clinical information of pSS patients was gathered and physicochemical tests were conducted.The clinical features of female and male patients were summarized and analyzed.Results 935 pSS cases were collected,among which 65 cases were male.The male-female ratio was 0.7∶ 10.The man's median duration of diagnosis was 10 months,with a median duration of 36 months,compared with women's time (P ＜ 0.05).There were significant statistical differences between both the dry mouth and dry eyes occurrence rate of female and male patients (P ＜ 0.05).In ophthalmic Schirmer tests,440 female patients and 8 male presented abnormal results (P ＜ 0.05).For labial gland biopsy,the positive rate of male patients was much higher than that of the female (P ＜ 0.05).The incidence of lymphadenectasis of male patients was 16.9％,which was higher than that of female patients (5.2％),presenting statistical significance (P ＜ 0.05).As regards pSS system lesions,54.48％ of the female presenting presented system lesions,while this rate for male patients was only 36.92％;the rate of multiple system lesions for female and male patients was 10.8％ and 3％ (P ＜ 0.05).The incidence of lymphadenectasis of male patients was higher than that of female patients (P ＜ 0.05).As regards pSS system lesions,the incidence of multiple system involvement was low(P ＜ 0.05).Conclusion The incidence of male pSS is significantly lower than that of female.Dry mouth dryness is lower than that of female,and there is no difference in digestive,respiratory,urinary and nervous system involvement.