Clinical effect of mosapride combined with rabeprazole in the treatment of elderly patients with reflux esophagitis / 中国基层医药

ABSTRACT

Objective To explore the clinical effect of mosapride combined with rabeprazole in the treatment of elderly patients with reflux esophagitis .Methods Clinical data of 126 elderly patients with reflux esophagitis were retrospectively studied.64 cases in the study group were treated with mosapride combined with rabeprazole ,62 cases in the control group were treated with mosapride combined with omeprazole .The clinical effects between the two groups were compared.Results Before treatment,there were no statistically significant differences in the scores of pain of patients with heartburn,acid reflux and chest between the two groups (t =0.512,0.181,0.228,all P >0.05). After treatment,the symptom scores of the study group were significantly lower than those of the control group (t =3.689,4.892,5.571,all P <0.01).The clinical symptoms and esophageal mucosal total effective rate in the study group were significantly higher than those in the control group (96.88% vs.87.10%,93.75% vs.80.65%,χ2 =4.121,4.479,all P <0.05).The scores of quality of life scale of the study group were significantly higher than those of the control group in cognitive function ,mental function,physical function and social function (t =4.920,6.853, 4.153,6.163,all P <0.01).Conclusion Mosapride combined with rabeprazole in the treatment of elderly patients with reflux esophagitis can effectively relieve symptoms of heartburn ,acid reflux and chest pain,help patients with mucosa recovery as soon as possible ,improve the quality of life of patients,and it is worthy of clinical application .