Comparison of clinical features and prognosis in patients with accidental N1 phase and expected N1 phase of non-small cell lung cancer / 中国综合临床

ABSTRACT

Objective To compare the clinical features and prognosis in patients with accidental N1 phase and expected N1 phase of non-small cell lung cancer( NSCLC) . Methods Retrospective analysis was performed on the one hundred and seventy-six NSCLC patients who underwent surgery and were pathologically diagnosed with pT1-3N1M0 phase NSCLC from January 2008 to June 2012. Among them,there were 75 patients with accidental N1 disease (cN0-pN1) NSCLC (accidental group),and 101 patients with expected N1 disease (cN1-pN1) NSCLC (clinical group). The clinical features,metastasis and recurrence,survival time,1,3,5-year survival rates of the two groups were analyzed. Results There were significant differences in tumor diameter, pathologic T staging,the number of lymph node metastasis and the number of stations between the two groups (P<0. 05) . The local recurrence rate of the patients in the accident group was 10. 7% ( 8/ 75), which was significantly lower than that in the clinical group 21. 8% ( 22/ 101), and the difference was statistically significant (χ2 = 7. 988,P= 0. 039). The survival time of accidental group was (46. 8±5. 5) months,compared with the expected group ((29. 7±4. 9) months),it was obviously prolonged (t = 8. 665,P = 0. 029). The 1,3 and 5 year survival rates in the accident group were 85. 3% (64/ 75),57. 3% (43/ 75),42. 7% (32/ 75), respectively,which were significantly higher than those in the clinical group (73. 3% (74/ 101),43. 6% (44/101),28. 7% (29/ 101)) (χ2 = 6. 089,7. 490,9. 112,P<0. 05). Conclusion The clinical manifestations are different. N1 phase NSCLC patients have a certain degree of heterogeneity. Accidental N1 phase NSCLC patients have obvious advantages in local recurrence and long-term survival than those with clinical N1 phase NSCLC.