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Does Intravenous Ketamine Enhance Analgesia after Arthroscopic Shoulder Surgery with Ultrasound Guided Single-Injection Interscalene Block?: A Randomized, Prospective, Double-Blind Trial
Journal of Korean Medical Science ; : 1001-1006, 2014.
Article in English | WPRIM | ID: wpr-70743
ABSTRACT
Ketamine has anti-inflammatory, analgesic and antihyperalgesic effect and prevents pain associated with wind-up. We investigated whether low doses of ketamine infusion during general anesthesia combined with single-shot interscalene nerve block (SSISB) would potentiate analgesic effect of SSISB. Forty adult patients scheduled for elective arthroscopic shoulder surgery were enrolled and randomized to either the control group or the ketamine group. All patients underwent SSISB and followed by general anesthesia. During an operation, intravenous ketamine was infused to the patients of ketamine group continuously. In control group, patients received normal saline in volumes equivalent to ketamine infusions. Pain score by numeric rating scale was similar between groups at 1, 6, 12, 24, 36, and 48 hr following surgery, which was maintained lower than 3 in both groups. The time to first analgesic request after admission on post-anesthesia care unit was also not significantly different between groups. Intraoperative low dose ketamine did not decrease acute postoperative pain after arthroscopic shoulder surgery with a preincisional ultrasound guided SSISB. The preventive analgesic effect of ketamine could be mitigated by SSISB, which remains one of the most effective methods of pain relief after arthroscopic shoulder surgery.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain, Postoperative / Arthroscopy / Shoulder / Time Factors / Pain Measurement / Brachial Plexus / Double-Blind Method / Prospective Studies / Analgesia, Patient-Controlled / Analgesics Type of study: Controlled clinical trial / Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pain, Postoperative / Arthroscopy / Shoulder / Time Factors / Pain Measurement / Brachial Plexus / Double-Blind Method / Prospective Studies / Analgesia, Patient-Controlled / Analgesics Type of study: Controlled clinical trial / Observational study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Journal of Korean Medical Science Year: 2014 Type: Article