Regular Exercise Training Increases the Number of Endothelial Progenitor Cells and Decreases Homocysteine Levels in Healthy Peripheral Blood
The Korean Journal of Physiology and Pharmacology
;
: 163-168, 2014.
Article
in English
| WPRIM
| ID: wpr-727680
ABSTRACT
Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damaged blood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determine whether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells was measured after a 28-day regular exercise training program. The number of total endothelial progenitor cell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group (p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by an increase in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise training could increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inverse correlation was observed between small-endothelial progenitor cell colony-forming units (small-EPC-CFUs) and plasma homocysteine levels in healthy men (r=-0.8125, p=0.047). We found that regular exercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thus decreasing the cardiovascular disease risk in men.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Stem Cells
/
Blood Vessels
/
Cardiovascular Diseases
/
Education
/
Homocysteine
Limits:
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Physiology and Pharmacology
Year:
2014
Type:
Article
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