Relationship of MMP-2 or TGF-β2 levels in human vitreous with axial length / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM:To investigate the relationship of matrix metalloproteinase-2(MMP-2)and transforming growth factor-beta 2(TGF-β2)levels in human vitreous with axial length(AL)of patients with high myopia.<p>METHODS: The concentrations of MMP-2 and TGF-β2 levels were tested by Enzyme-Linked Immunosorbnent Assay(ELISA). Fifty-five human vitreous samples of 55 patients were collected during vitrectomy surgery, and were divided into two groups according to their spherical equivalent(SE)and axial length(AL). High myopia group(25 cases) SE>-6.00D, AL≥26.00mm, and control group or non-high myopia group(30 cases) SE≤-6.00D, AL<26.00mm.<p>RESULTS: The MMP-2 levels in vitreous of high myopia group(96.87±55.95ng/mL)was significantly higher than that of control group(77.24±41.81ng/mL, <i>P</i><0.05), but not correlated with AL(<i>r</i>=0.088, <i>P</i>=0.544). While the TGF-β2 vitreous concentration was negatively correlated with AL(<i>r</i>=-0.344, <i>P</i>=0.014), and there was significant difference of TGF-β2 vitreous levels between high myopia group(3729.08±1890.88pg/mL)and control group(3926.00±1333.88pg/mL, <i>P</i><0.05).<p>CONCLUSION: MMP-2 and TGF-β2 in human vitreous may play a critical role in human high myopia development, and the TGF-β2 appears to be associated with axial length.