The correlation analysis of donor renal histopathology scores with Lifeport parameters and donor grades / 中华器官移植杂志

ABSTRACT

Objective To analyze the relationship of donor kidney histopathology scores with Lifeport parameters and donor grades before kidney transplantation.Methods Retrospective analysis was including 25 cases of organ donation (DCD) donor kidney transplantation from January 2017 to May 2018.The correlation analysis was performed on histopathological data of donor kidney,Lifeport parameters,and donor grades.Histopathological examination was carried out by rapid paraffin method,and the scores were graded according to the Remuzzi standard and acute tubular injury (ATI) degree.The donor grades were based on the standard score of our center.Data were analyzed by SPSS(R) 17.0 software.Results Remuzzi scores were positively correlated with protopathy scores (r =0.546,P =0.005) and hypertension scores of donor scores (r =0.500,P =0.011).Remuzzi scores and Lifeport parameters flow (Flow) and resistance index (RI) were found to be correlated.Remuzzi scores of glomeruli sclerosis (GS),tubule atrophy (TA),interstitial fibrosis (IF),arterial narrow (AN) and Lifeport parameters were also correlated,among which the correlation of AN scores were strongest correlated with Lifeport parameters (Flowr =0.539,P＜0.001;RIr =0.497,P =0.001).ATI had a correlation with Lifeport parameters (Flowr =0.368,P =0.016;RIr =0.456,P =0.002),which is most relevant to the RI.However,there was no correlation of the donor grades with Lifeport parameters,and ATI (Flowr=0.216,P =0.169;RIr=0.06,P =0.707;ATIr =0.005,P =0.977).Of 50 cases of kidney transplantation,recover time of DGF group was significantly higer than that of nomal recovery group F =14.729,P =0.001);Lifeport flow parameters of normal recovery group were statistically higher than those of other groups (F =3.612,P =0.020).Conclusion Histopathology scores of donors kidney are correlated with protopathy scores,hypertension scores,and Lifeport parameters,and could be used to evaluate the renal quality effectively.In the clinical work,the donor grades,histopathology scores and Lifeport parameters should be combined to evaluate the kidney quality.