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The Role of Tripartite Motif Family Proteins in TGF-β Signaling Pathway and Cancer
Journal of Cancer Prevention ; : 162-169, 2018.
Article in English | WPRIM | ID: wpr-740115
ABSTRACT
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated at various levels, including transcriptional and post-translational mechanisms. Ubiquitination of signaling components, such as receptors and Smad proteins is one of the key regulatory mechanisms of TGF-β signaling. Tripartite motif (TRIM) family of proteins is a highly conserved group of E3 ubiquitin ligase proteins that have been implicated in a variety of cellular functions, including cell growth, differentiation, immune response, and carcinogenesis. Recent emerging studies have shown that some TRIM family proteins function as important regulators in tumor initiation and progression. This review summarizes current knowledge of TRIM family proteins regulating the TGF-β signaling pathway with relevance to cancer.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Transforming Growth Factor beta / Ubiquitin / Ubiquitin-Protein Ligases / Smad Proteins / Ubiquitination / Carcinogenesis Limits: Humans Language: English Journal: Journal of Cancer Prevention Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Transforming Growth Factor beta / Ubiquitin / Ubiquitin-Protein Ligases / Smad Proteins / Ubiquitination / Carcinogenesis Limits: Humans Language: English Journal: Journal of Cancer Prevention Year: 2018 Type: Article