Augmented renal clearance
Translational and Clinical Pharmacology
; : 111-114, 2018.
Article
in En
| WPRIM
| ID: wpr-742415
Responsible library:
WPRO
ABSTRACT
Adding to the complexity of caring for critically ill patients is the fact that many of them have a creatinine clearance that exceeds 130 mL/min/1.73 m². This phenomenon, termed augmented renal clearance (ARC), has only recently been widely recognized and its pathogenesis remains incompletely understood. However, ARC has been shown to result in increased dose requirements for drugs that are primarily eliminated by renal excretion, including many antimicrobial agents and enoxaparin. Recognition of ARC is hampered by the fact that the standard creatinine-based equations used to estimate renal function are not accurate in this clinical setting and the diagnosis is best established using both serum and urine creatinine measurements to calculate clearance. So a high index of clinical suspicion and awareness is usually required before this step is taken to confirm the diagnosis of ARC.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Critical Illness
/
Enoxaparin
/
Creatinine
/
Diagnosis
/
Renal Elimination
/
Anti-Infective Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Translational and Clinical Pharmacology
Year:
2018
Type:
Article