Your browser doesn't support javascript.
loading
Prognostic Value of Lymphovascular Invasion in Node-Negative Upper Urinary Tract Urothelial Carcinoma Patients Undergoing Radical Nephroureterectomy
Yonsei Medical Journal ; : 174-181, 2019.
Article in English | WPRIM | ID: wpr-742521
ABSTRACT

PURPOSE:

This study aimed to evaluate the prognostic impact of lymphovascular invasion (LVI) in patients treated with radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC). MATERIALS AND

METHODS:

We collected data from 180 patients who were treated with RNU from 2005 to 2013 at our institution. The Kaplan-Meier method with log-rank test and Cox proportional hazards regression models were used for univariate and multivariate analyses.

RESULTS:

LVI was present in 28 patients (15.6%), which was associated with higher pathological tumor stage (p < 0.001), tumor necrosis (p=0.012), lymph node metastasis (p=0.017) and multifocality (p=0.012). On multivariate analysis, LVI was an independent prognostic factor of recurrence-free survival [RFS hazard ratio (HR)=2.954; 95% confidence interval (CI)=1.539–5.671; p=0.001] and cancer-specific survival (CSS HR=3.530; 95% CI=1.701–7.325; p=0.001) in all patients. In patients with node-negative UTUC, LVI was also a significant predictor of RFS (HR=3.732; 95% CI 1.866–7.464; p < 0.001) and CSS (HR=3.825; 95% CI=1.777–8.234; p=0.001).

CONCLUSION:

LVI status was an independent predictor in patients with UTUC who underwent RNU. The estimate of LVI could help physicians identify high-risk patients and make a better medication regimen of adjuvant chemotherapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Urinary Tract / Carcinoma, Transitional Cell / Multivariate Analysis / Chemotherapy, Adjuvant / Lymph Nodes / Methods / Necrosis / Neoplasm Invasiveness / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Urinary Tract / Carcinoma, Transitional Cell / Multivariate Analysis / Chemotherapy, Adjuvant / Lymph Nodes / Methods / Necrosis / Neoplasm Invasiveness / Neoplasm Metastasis Type of study: Prognostic study Limits: Humans Language: English Journal: Yonsei Medical Journal Year: 2019 Type: Article